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Alcohol flush reaction. It has also been associated with lower than average rates of alcoholism, possibly due to its association with adverse effects after drinking alcohol. Approximately 36% of East Asians (Chinese, Japanese, and Koreans) show characteristic physiological responses to drinking alcohol that includes facial flushing, nausea, head-aches and tachycardia.

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Asians and Alcohol. As a result, acetaldehyde, a toxic byproduct of alcohol, isn’t broken down to harmless acetic acid, but instead builds up in the blood and liver. This dilates blood vessels, leading to flushing (redness and heat) in the face, neck, and sometimes shoulders and entire body. Headaches, dizziness, palpitations, and nausea may also occur.


Mar 10, · When most people consume alcohol, it is processed by two liver enzymes. The first, alcohol dehydrogenase, converts the alcohol to acetaldehyde. The second, aldehyde dehydrogenase, converts the acetaldehyde into acetic acid, which can then be broken down into carbon dioxide. Abstract. Current knowledge is examined about the influence of various ethanol metabolizing enzymes on alcohol consumption by Asians and members of other ethnic groups. The two principal enzymes involved in ethanol oxidative metabolism are alcohol dehydrogenase (ADH) .
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They just laugh it off and tell you it’s an “Asian flush.”. The Asian flush, sometimes called the “Asian glow,” refers to a common reaction to alcohol among East Asians. This facial flushing was found to be a result of a deficiency of a liver enzyme called ALDH2. This finding was revealed in .

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Alcohol Flush Signals Increased Cancer Risk among East Asians. East Asians have two main variants of the ALDH2 gene — one that produces an enzyme with normal activity, and another that results in an inactive enzyme. When individuals with the inactive variant drink alcohol, acetaldehyde accumulates in the body, resulting in facial flushing, nausea. Are Asians Allergic to Alcohol. Asian flush, being a condition when one’s face and upper-body turns rapidly red, can occur even after only 2 sips of alcohol. This can be a big problem if all you want to do is enjoy a glass of wine over dinner, or have a martini while at an after-work party with your rapidshoot.info: James Rowe.

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Why Indians are alcoholics and Asians can’t drink. Unlike the American Indians the Chinese and Japanese produce a lot of ADH. 85% of their population produces unusual high activities of this enzyme. Where Caucasians score less than 21%, African Americans less than 10% and Native Americans as well as Asian Indians 0%. Alcohol dehydrogenase. Alcohol dehydrogenases (ADH) (EC ) are a group of dehydrogenase enzymes that occur in many organisms and facilitate the interconversion between alcohols and aldehydes or ketones with the reduction of nicotinamide adenine dinucleotide (NAD + to NADH).BRENDA: BRENDA entry.

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The main method that the body metabolises or breaks down alcohol is dependent on two enzymes: Alcohol dehydrogenase which first converts alcohol into acetaldehyde and; Acetaldehyde dehydrogenase (ALDH2) which breaks down acetaldehyde into harmless compounds. Due to genomic differences, 80 per cent of Asians have an overactive alcohol dehydrogenase.
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